Iris Morphologic Changes Related to α1-Adrenergic Receptor Antagonists
نویسندگان
چکیده
منابع مشابه
Endothelin antagonists block α1-adrenergic constriction of coronary arterioles.
We have previously observed that intracoronary administration of the α1-adrenergic agonist phenylephrine (PE) over a period of minutes induced both an immediate and long-lasting (2 h) vasoconstriction of epicardial coronary arterioles. Because it is unlikely that α1-adrenergic constriction would persist for hours after removal of the agonist, this observation supports the view that another cons...
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RATIONALE The coordination of vascular smooth muscle cell constriction plays an important role in vascular function, such as regulation of blood pressure; however, the mechanism responsible for vascular smooth muscle cell communication is not clear in the resistance vasculature. Pannexins (Panx) are purine-releasing channels permeable to the vasoconstrictor ATP and thus may play a role in the c...
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Background: Alveolar hypoxia induces monophasic pulmonary vasoconstriction in vivo, biphasic vasoconstriction in the isolated pulmonary artery, and controversial responses in the isolated perfused lung. Pulmonary vascular responses to sustained alveolar hypoxia have not been addressed in the isolated perfused rat lung. In this study, we investigated the effect of sustained hypoxic ventilation o...
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BACKGROUND Agonistic autoantibodies directed at the alpha(1)-adrenergic receptor (alpha(1)-AAB) have been described in patients with hypertension. We implied earlier that alpha(1)-AAB might have a mechanistic role and could represent a therapeutic target. METHODOLOGY/PRINCIPAL FINDINGS To pursue the issue, we performed clinical and basic studies. We observed that 41 of 81 patients with refrac...
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ژورنال
عنوان ژورنال: Ophthalmology
سال: 2009
ISSN: 0161-6420
DOI: 10.1016/j.ophtha.2008.12.040